The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by CHEESE restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar attachments to the mitotic spindle.Its malfunction can lead to cancer.We have constructed and v
The incidence of breast cancer increases with age.Particularly in ageing societies, breast cancer has a significant impact on both the older patient and the healthcare system.In older patients with early breast cancer, there is a complex interplay between (i) tumor biology, (ii) risk of recurrence, (iii) comorbidities, (iv) frailty, (v) life expect
Brucellosis is a systemic bacterial zoonotic disease with potential endovascular Crutches complications including endocarditis, although multifocal vasculopathy is rare.Moreover, swine-associated human infections are less common since brucellosis was eradicated in commercial swine in U.S.states and territories.However, feral swine continue to serve
The analysis of the state of the hop industry in Ukraine, the USA, China and the EU countries has been carried out.The reasons for the decline of the industry in Ukraine in the last three decades have been determined.Among them noted: the scientific unreasonableness of the dispersal of hop plantations and integrated valuable assets of hops; the cha